Physician office
Treat in the office and bill G0465 with one E code and one L code.
- 2026 national payment: $1,064.49
- MPFS status code A
Autologous whole blood clot
Healing chronic wounds with the patient's own blood.
NexaBiologics brings a point-of-care wound therapy to your patients. Their fresh whole blood becomes a protective clot in about five minutes, right where you treat them, with no centrifuge and no lab.
- ~5 min to prepare
- 51% vs 18% complete healing in an RCT1
- G0465 Medicare coverage
The therapy
A personalized approach to wound management
The autologous whole blood clot is made from your patient's peripheral blood. Once applied, it serves as a protective covering and may optimize the body's own healing potential.
Whole blood, not a concentrate. Red and white cells, platelets, plasma and fibrin stay together, forming both a scaffold and a source of growth factors.
- Platelets
- A rich source of biologically active growth factors.
- Extracellular matrix
- Functional ECM that enables cell adhesion and granulation tissue formation.
- Endogenous cells
- Macrophages coordinate the healing process, modulate inflammation, source growth factors and enable granulation tissue formation.
- Works on thinners
- Complete clots formed from the blood of patients on warfarin or rivaroxaban in an ex vivo study.
- Autologous
- Nothing donated, nothing stored. A good fit for patients with religious constraints on donor tissue.
Proven outcomes
More patients healed than with standard care alone
In a multicenter randomized controlled trial in diabetic foot ulcers, patients treated with the autologous whole blood clot healed far more often than patients on standard of care.
- 173%more patients healed in the intervention arm (ITT population)
- 2.73odds ratio for complete healing versus standard of care
- 28 cm²one clot can cover a wound up to 56 cm²
Streamlined procedure
Mix, apply, heal, in a single visit
Each system arrives ready to use. Draw blood, let it clot in the mold, and place it in the wound bed. Blood can be drawn and stored for up to 24 hours before the procedure.
STEP 1
Mix
Draw about 20 mL of blood into two ACD-A tubes and inject it into the coagulation mold, where it mixes with a proprietary kaolin and calcium gluconate powder. The clot forms in minutes.
STEP 2
Apply
Lift the clot by its rim, trim it to fit, and place it gauze side up so it fills the whole wound bed. Secure with strips and cover with non-adherent and foam dressings.
STEP 3
Heal
The clot promotes the healing cascade and protects the wound. Remove it after about seven days, reassess, and reapply weekly as needed.
ProductRD22015 systems per box
Clot size28 cm²Covers wounds up to 56 cm²
Storage41–86 °F5–30 °C, protect from freezing
EquipmentNoneNo centrifuge or power needed
Read the full preparation guide
Summarized from the manufacturer's Instructions for Use. Always follow the full IFU supplied with the kit. Rx only.
Where it's used
Goes wherever your patients are
With nothing to spin, store or ship, the whole blood clot fits a physician office, a hospital outpatient department, or a mobile wound care visit.
Hospital outpatient
Use in on-campus or off-campus outpatient departments under the OPPS.
- 2026 OPPS national average: $2,107.97
- APC 5054, status T
Mobile wound care
Draw, mix and apply in a single bedside visit at home, in assisted living, or in a skilled nursing facility.
- Short visits, nothing to store
- Check Part A SNF consolidated billing
Ideal candidates
- Chronic diabetic foot ulcers stalled on standard care and open 4+ weeks
- Adequate perfusion, infection controlled, glucose and nutrition addressed
- Offloading or compression in place
- Other hard-to-heal wounds where the payer covers it
Before you begin
- Contraindicated for wounds due to malignancy or with active, clinically diagnosed infection
- EtO-sterilized components can cause serious allergic reactions in sensitized patients
- If pain increases after application, consider removing the clot to check for infection
- Use alongside standard of care: debridement, offloading, compression
Choose with confidence
Reimbursable as a blood-derived product
CMS covers autologous blood-derived products for chronic non-healing diabetic ulcers for up to 20 weeks under NCD 270.3. It is not a skin substitute. Three code types make up one claim.
G
The procedure
G0465 for diabetic chronic ulcers. G0460 for non-diabetic chronic ulcers, priced by your local MAC. Phlebotomy, prep, application and dressings are bundled per treatment.
E
The diabetes diagnosis
One ICD-10-CM code, E08 through E13. .621 is with foot ulcer, .622 is with other skin ulcer. Required with G0465.
L
The ulcer diagnosis
L97 for the lower limb, L98 for other sites. The last digit gives depth, from skin breakdown to bone involvement.
| Code | Use | Coverage | 2026 Medicare payment |
|---|---|---|---|
| G0465 | Diabetic chronic wounds | National, up to 20 weeks; after that, MAC discretion with modifier KX | Office $1,064.49 HOPD $2,107.97 |
| G0460 | Non-diabetic chronic wounds | Local MAC decision | Contractor priced |
Illustrative claim line
G0465 + E11.621 + L97.512
Type 2 diabetes with a foot ulcer, on the other part of the right foot with the fat layer exposed. Code selection must reflect the patient's documented condition.
- Verify firstCall our reimbursement team for benefit verification and prior authorization before treating.
- Document to support the codesChart the ulcer's site, depth and diabetes status. Claims without both an E and an L code may be denied.
- Extend with KXAt 21+ weeks, document continued progress and why more applications are needed, and append modifier KX.
- Confirm locallyCheck your MAC and private payers for current payment. Commercial payer policies vary.
For patients
Your body already knows how to heal. We help it along.
If you have a wound that has not healed after weeks of care, ask your doctor whether an autologous whole blood clot could be part of your treatment.
What is it?
A small amount of your own blood is drawn, turned into a soft clot in a few minutes, and placed over your wound to protect it and support healing.
Does it use anyone else's blood or tissue?
No. Everything comes from you, and it is made fresh at each visit.
What happens at a visit?
Your provider measures and cleans the wound, draws two small tubes of blood, applies the clot and covers it with a dressing. The clot stays on for about a week.
Is it covered?
Medicare covers it for chronic diabetic ulcers. Our team can help your provider check your plan.
Guides
Clinical and billing guides
Download the same references our team uses with practices and facilities.
PDFProduct overviewThe therapy, outcomes and billing at a glance, office setting, 2026
PDFPreparation guidePoint-of-care steps from blood draw to clot removal
PDFBilling guide: physician officeG, E and L codes with 2026 MPFS payment
PDFBilling guide: hospital outpatientG, E and L codes with 2026 OPPS payment
Contact
Order, verify benefits, or ask a question
Our order, customer support and reimbursement team works with practices, hospitals and mobile wound care groups.
- Ordering and product questions
- Benefit verification and prior authorization
- Coding, billing and reimbursement
- Phone
- (919) 617-6392